Lipid metabolism, adipocyte depot physiology and utilization of meat animals as experimental models for metabolic research

نویسندگان

  • Michael V. Dodson
  • Gary J. Hausman
  • LeLuo Guan
  • Min Du
  • Theodore P. Rasmussen
  • Sylvia P. Poulos
  • Priya Mir
  • Werner G. Bergen
  • Melinda E. Fernyhough
  • Douglas C. McFarland
  • Robert P. Rhoads
  • Beatrice Soret
  • James M. Reecy
  • Sandra G. Velleman
  • Zhihua Jiang
چکیده

Meat animals are unique as experimental models for both lipid metabolism and adipocyte studies because of their direct economic value for animal production. This paper discusses the principles that regulate adipogenesis in major meat animals (beef cattle, dairy cattle, and pigs), the definition of adipose depot-specific regulation of lipid metabolism or adipogenesis, and introduces the potential value of these animals as models for metabolic research including mammary biology and the ontogeny of fatty livers.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Control of Adipocyte Differentiation in Different Fat Depots; Implications for Pathophysiology or Therapy

Adipocyte differentiation and its impact on restriction or expansion of particular adipose tissue depots have physiological and pathophysiological significance in view of the different functions of these depots. Brown or "beige" fat [brown adipose tissue (BAT)] expansion can enhance thermogenesis, lipid oxidation, insulin sensitivity, and glucose tolerance; conversely expanded visceral fat [vis...

متن کامل

Alterations in lipid metabolism and thermogenesis with emergence of brown adipocytes in white adipose tissue in diet-induced obesity-resistant Lou/C rats.

Recent studies describe the Lou/C rat as a model of resistance to age- and diet-induced obesity and suggest a preferential channeling of nutrients toward utilization rather than storage under standard feeding conditions. The purpose of the present study was to evaluate lipid metabolism of Lou/C and Wistar rats under a high-fat (HF) diet. Four-month-old male Lou/C and Wistar animals were submitt...

متن کامل

Fasting and Experimental Animals, Detrimental or Positive?

While fasting has been practiced for centuries, its beneficial effects was unknown until recently. This review tries to analyze the current literature of how fasting and intermittent fasting (IF) could affect clinical pathological parameters, learning, mood and brain plasticity. The effects of different ways of fasting on metabolism and stress were also explored. Animal experiments have elucida...

متن کامل

A cellular model for the investigation of depot specific human adipocyte biology

Upper-body adiposity is associated with increased metabolic disease risk, while lower-body adiposity is paradoxically protective. Efforts to understand the underlying mechanisms require appropriate and reproducible in vitro culture models. We have therefore generated immortalised (im) human preadipocyte (PAD) cell lines derived from paired subcutaneous abdominal and gluteal adipose tissue. Thes...

متن کامل

The adipocyte as an important target cell for Trypanosoma cruzi infection.

Adipose tissue plays an active role in normal metabolic homeostasis as well as in the development of human disease. Beyond its obvious role as a depot for triglycerides, adipose tissue controls energy expenditure through secretion of several factors. Little attention has been given to the role of adipocytes in the pathogenesis of Chagas disease and the associated metabolic alterations. Our prev...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 6  شماره 

صفحات  -

تاریخ انتشار 2010